Pediatric Chronic Myelogenous Leukemia in T-lineage Blast Crisis: A Reminder in Relevance

Research output: Contribution to journalArticlepeer-review

Abstract

Pediatric Philadelphia chromosome positive (Ph+) acute T-cell lymphoblastic leukemia can mimic chronic myelogenous leukemia (CML) in T-lineage blast crisis (BC). Differentiating the 2 is critical in guiding therapy as most children with de novo Ph+ acute T-cell lymphoblastic leukemia are treated with chemotherapy and tyrosine kinase inhibitors, whereas T-lineage BC of CML can include hematopoietic stem cell transplantation. We present a unique case of CML in T-lineage BC. The patient was treated with induction chemotherapy plus imatinib followed by matched unrelated donor hematopoietic stem cell transplantation. She is currently off all medications and in complete disease remission.

Original languageEnglish (US)
Pages (from-to)707-708
Number of pages2
JournalJournal of Pediatric Hematology/Oncology
Volume44
Issue number3
DOIs
StatePublished - Apr 1 2022

Keywords

  • BCR-ABL1
  • Blast crisis
  • Chronic myelogenous leukemia
  • Philadelphia chromosome
  • T-cell acute lymphoblastic leukemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Pediatric Chronic Myelogenous Leukemia in T-lineage Blast Crisis: A Reminder in Relevance'. Together they form a unique fingerprint.

Cite this