Pediatric Ventilator-Associated Events: Analysis of the Pediatric Ventilator-Associated Infection Data

Douglas F. Willson, Mark Hall, Andrew Beardsley, Michelle Hoot, Aileen Kirby, Spencer Hays, Simon Erickson, Edward Truemper, Robinder Khemani

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objectives: To compare the prevalence of infection applying the proposed pediatric ventilator-associated events criteria versus clinician-diagnosed ventilator-associated infection to subjects in the pediatric ventilator-associated infection study. Design: Analysis of prospectively collected data from the pediatric ventilator-associated infection study. Setting: PICUs of 47 hospitals in the United States, Canada, and Australia. Patients: Two-hundred twenty-nine children ventilated for greater than 48 hours who had respiratory secretion cultures performed to evaluate for suspected ventilator-associated infection. Interventions: None. Measurements and Main Results: Applying the proposed pediatric ventilator-associated event criteria, 15 of 229 subjects in the ventilator-associated infection study qualified as "ventilator-associated condition" and five of 229 (2%) met criteria for "infectionrelated ventilator-associated complication." This was compared with 89 of 229 (39%) diagnosed as clinical ventilator-associated infection (Kappa = 0.068). Ten of 15 subjects identified as ventilator- associated condition did not meet criteria for infection-related ventilator-associated complication primarily because they did not receive 4 days of antibiotics. Ventilator-associated condition subjects were similar demographically to nonventilator-associated condition subjects and had similar mortality (13% vs 10%), PICU-free days (6.9 ± 7.7; interquartile range, 0-14 vs 9.8 ± 9.6; interquartile range, 0-19; p = 0.25), but fewer ventilator-free days (6.6 ± 9.3; interquartile range, 1-15 vs 12.4 ± 10.7; interquartile range, 0-22; p = 0.04). The clinical ventilator-associated infection diagnosis in the ventilator-associated infection study was associated with fewer PICU-free days but no difference in mortality or ventilator-free days. Conclusions: The ventilator-associated event criteria appear to be insensitive to the clinical diagnosis of ventilator-associated infection. Differentiation between ventilator-associated condition and infectionrelated ventilator-associated complication was primarily determined by the clinician decision to treat with antibiotics rather than clinical signs and symptoms. The utility of the proposed pediatric ventilatorassociated event criteria as a surrogate for ventilator-associated infection criteria is unclear.

Original languageEnglish (US)
Pages (from-to)E631-E636
JournalPediatric Critical Care Medicine
Issue number12
StatePublished - Dec 1 2018


  • Antibiotics
  • Nosocomial infection
  • Ventilator-associated events
  • Ventilator-associated infection
  • Ventilator-associated pneumonia
  • Ventilator-associated tracheitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine


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