Peptide YY as a growth factor for intestinal epithelium

Peter J. Mannon

doi:10.1016/S0196-9781(01)00615-5

Peptide YY as a growth factor for intestinal epithelium

Peter J. Mannon

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth.

Original language	English (US)
Pages (from-to)	383-388
Number of pages	6
Journal	Peptides
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/S0196-9781(01)00615-5
State	Published - 2002
Externally published	Yes

Keywords

Epidermal growth factor receptor
Epithelium
Growth
Mitogen-activated protein kinase
Peptide YY
Receptor

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/S0196-9781(01)00615-5

Cite this

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title = "Peptide YY as a growth factor for intestinal epithelium",

abstract = "Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth.",

keywords = "Epidermal growth factor receptor, Epithelium, Growth, Mitogen-activated protein kinase, Peptide YY, Receptor",

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PY - 2002

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AB - Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth.

KW - Epidermal growth factor receptor

KW - Epithelium

KW - Growth

KW - Mitogen-activated protein kinase

KW - Peptide YY

KW - Receptor

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DO - 10.1016/S0196-9781(01)00615-5

M3 - Article

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JO - Peptides

JF - Peptides

IS - 2

ER -

Peptide YY as a growth factor for intestinal epithelium

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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