Peptide YY as a growth factor for intestinal epithelium

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalPeptides
Volume23
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Epidermal growth factor receptor
  • Epithelium
  • Growth
  • Mitogen-activated protein kinase
  • Peptide YY
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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