Periocular lymphoproliferative diseases: Natural history, prognostic factors, and treatment

B. A. Erickson, G. J. Harris, C. A. Enke, K. J. Murray, B. M. Massaro, G. A. Hanson, R. M. Hansen, T. Anderson, J. F. Wilson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A study was undertaken to assess the natural history of periocular lymphoproliferative diseases, identify key prognostic factors, and clarify the role of orbital irradiation. Thirty-four patients with periocular lymphoproliferative disease were treated with orbital irradiation between 1975 and 1990. Eight patients had atypical lymphoid infiltrate, and 26 had malignant lymphoma. Forty-three eyes were irradiated with en-face electrons or 6-MV photons. Five-year disease-free survival for all stages was 65%; it was not significantly affected by bilaterality or site. Stage, distinction between atypical lymphoid infiltrate and malignant lymphoma, and working formulation grade were important prognostic indicators. A complete response during irradiation was achieved in 24 of 43 (56%) eyes at a median dose of 2,400 cGy, and a partial response was achieved in 19 (44%), with resolution at a median of 2.8 months. Patients with periocular reactive lymphoid hyperplasia or atypical lymphoid infiltrate may have or are at significant risk of developing lymphoma and dissemination. Local treatment remains important; orbital irradiation achieves prompt local control with acceptable morbidity.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
Issue number1
StatePublished - 1992


  • Eye, neoplasms
  • Eye, therapeutic radiology
  • Lymphoma, therapy
  • Orbit, neoplasms
  • Orbit, therapeutic radiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Periocular lymphoproliferative diseases: Natural history, prognostic factors, and treatment'. Together they form a unique fingerprint.

Cite this