Abstract
Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.
Original language | English (US) |
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Pages (from-to) | 366-371 |
Number of pages | 6 |
Journal | Behavioural Brain Research |
Volume | 198 |
Issue number | 2 |
DOIs | |
State | Published - Mar 17 2009 |
Externally published | Yes |
Keywords
- Antidepressant
- Behavior
- Exercise
- Forced-swim test
- IGF-I
- Mouse
- Novelty-induced hypophagia
ASJC Scopus subject areas
- Behavioral Neuroscience