Peripheral levels of matrix metalloproteinase-9, interleukin-6, and C-reactive protein are elevated in patients with acute coronary syndromes: Correlations with serum troponin I

Athanassios Manginas, Evgenia Bei, Antigoni Chaidaroglou, Dimitrios Degiannis, Katerina Koniavitou, Vassilis Voudris, Gregory Pavlides, Demosthenis Panagiotakos, Dennis V. Cokkinos

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: Acute coronary syndromes (ACS) are characterized by activation of systemic and local inflammatory mediators. The interrelation between these soluble inflammatory markers and their association with markers of myocardial necrosis have not been extensively studied. Hypothesis: The study was undertaken to evaluate the association of the systemic levels of matrix metalloproteinase-9 (MMP-9) and the tissue inhibitor of metalloproteinase-1 (TMP-1), with C-reactive protein (CRP), interleukin-6 (IL-6), and serum troponin-I in patients admitted with ACS. Methods: Analysis of serum concentrations of the above inflammatory markers was performed in 53 patients with unstable angina (UA) and in 15 with non-ST-segment elevation myocardial infarction (NSTEMI) within 48 h of admission, and 34 patients with stable coronary artery disease. Results: Compared with patients with stable angina, those with ACS had elevated admission levels of MMP-9 (p = 0.04), CRP (p < 0.001), and IL-6 (p = 0.001), but not TMP-1 (p = 0.55). Compared with patients with UA, those with NSTEMI also had higher levels of IL-6 (p < 0.001), CRP (p = 0.002), and MMP-9 (p = 0.05). Conclusions: In patients with ACS, the admission levels of inflammatory mediators, including MMP-9, CRP, and IL-6 are significantly elevated, specifically in association with serum troponin I. Systemic and local markers of inflammatory activity may be directly associated with myocardial injury.

Original languageEnglish (US)
Pages (from-to)182-186
Number of pages5
JournalClinical Cardiology
Volume28
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Acute coronary syndrome
  • Inflammation
  • Matrix metalloproteinase-9
  • Troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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