Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Marcel Kaiser, Sergio Wittlin, Angela Nehrbass-Stuedli, Yuxiang Dong, Xiaofang Wang, Andrew Hemphill, Hugues Matile, Reto Brun, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

Original languageEnglish (US)
Pages (from-to)2991-2993
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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