TY - JOUR
T1 - Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
AU - Kaiser, Marcel
AU - Wittlin, Sergio
AU - Nehrbass-Stuedli, Angela
AU - Dong, Yuxiang
AU - Wang, Xiaofang
AU - Hemphill, Andrew
AU - Matile, Hugues
AU - Brun, Reto
AU - Vennerstrom, Jonathan L.
PY - 2007/8
Y1 - 2007/8
N2 - Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
AB - Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=34547638282&partnerID=8YFLogxK
U2 - 10.1128/AAC.00225-07
DO - 10.1128/AAC.00225-07
M3 - Article
C2 - 17562801
AN - SCOPUS:34547638282
SN - 0066-4804
VL - 51
SP - 2991
EP - 2993
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -