Persistence of ebola virus in ocular fluid during convalescence

Jay B. Varkey; Jessica G. Shantha; Ian Crozier; Colleen S. Kraft; G. Marshall Lyon; Aneesh K. Mehta; Gokul Kumar; Justine R. Smith; Markus H. Kainulainen; Shannon Whitmer; Ute Ströher; Timothy M. Uyeki; Bruce S. Ribner; Steven Yeh

doi:10.1056/NEJMoa1500306

Persistence of ebola virus in ocular fluid during convalescence

Jay B. Varkey, Jessica G. Shantha, Ian Crozier, Colleen S. Kraft, G. Marshall Lyon, Aneesh K. Mehta, Gokul Kumar, Justine R. Smith, Markus H. Kainulainen, Shannon Whitmer, Ute Ströher, Timothy M. Uyeki, Bruce S. Ribner, Steven Yeh

Research output: Contribution to journal › Article › peer-review

338 Scopus citations

Abstract

Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

Original language	English (US)
Pages (from-to)	2423-2427
Number of pages	5
Journal	New England Journal of Medicine
Volume	372
Issue number	25
DOIs	https://doi.org/10.1056/NEJMoa1500306
State	Published - Jun 18 2015
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJMoa1500306

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title = "Persistence of ebola virus in ocular fluid during convalescence",

abstract = "Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.",

author = "Varkey, {Jay B.} and Shantha, {Jessica G.} and Ian Crozier and Kraft, {Colleen S.} and Lyon, {G. Marshall} and Mehta, {Aneesh K.} and Gokul Kumar and Smith, {Justine R.} and Kainulainen, {Markus H.} and Shannon Whitmer and Ute Str{\"o}her and Uyeki, {Timothy M.} and Ribner, {Bruce S.} and Steven Yeh",

note = "Publisher Copyright: Copyright {\textcopyright} 2015 Massachusetts Medical Society.",

year = "2015",

month = jun,

day = "18",

doi = "10.1056/NEJMoa1500306",

language = "English (US)",

volume = "372",

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T1 - Persistence of ebola virus in ocular fluid during convalescence

AU - Varkey, Jay B.

AU - Shantha, Jessica G.

AU - Crozier, Ian

AU - Kraft, Colleen S.

AU - Lyon, G. Marshall

AU - Mehta, Aneesh K.

AU - Kumar, Gokul

AU - Smith, Justine R.

AU - Kainulainen, Markus H.

AU - Whitmer, Shannon

AU - Ströher, Ute

AU - Uyeki, Timothy M.

AU - Ribner, Bruce S.

AU - Yeh, Steven

PY - 2015/6/18

Y1 - 2015/6/18

N2 - Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

AB - Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

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JF - New England Journal of Medicine

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Persistence of ebola virus in ocular fluid during convalescence

Abstract

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