Persistent Hyper IgA as a Marker of Immune Deficiency: A Case Report

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2 Scopus citations


An elevated IgA level obtained in a 10-year-old male a year after an episode of pneumo-coccal sepsis led to the discovery of a broad-based IgG-specific antibody deficiency syndrome. The specifics of the case and pertinent literature are presented, including a discussion of the hyper-IgD syndrome. An elevated IgA, greater than two standard deviations above the expected age range should prompt a complete workup for selective antibody deficiency syndrome and adds an additional associated marker of an indolent hyper-IgD syndrome in a different clinical circumstance, although the lack of antibody response to vaccines is atypical of the hyper-IgD syndrome.

Original languageEnglish (US)
Article number30
Issue number2
StatePublished - Jun 2022


  • IgA
  • immunodeficiency
  • pediatric

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Drug Discovery


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