Persistent Joint Pain Following Arthropod Virus Infections

Karol Suchowiecki, St Patrick Reid, Gary L. Simon, Gary S. Firestein, Aileen Chang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Purpose of Review: Persistent joint pain is a common manifestation of arthropod-borne viral infections and can cause long-term disability. We review the epidemiology, pathophysiology, diagnosis, and management of arthritogenic alphavirus infection. Recent findings: The global re-emergence of alphaviral outbreaks has led to an increase in virus-induced arthralgia and arthritis. Alphaviruses, including Chikungunya, O’nyong’nyong, Sindbis, Barmah Forest, Ross River, and Mayaro viruses, are associated with acute and/or chronic rheumatic symptoms. Identification of Mxra8 as a viral entry receptor in the alphaviral replication pathway creates opportunities for treatment and prevention. Recent evidence suggesting virus does not persist in synovial fluid during chronic chikungunya infection indicates that immunomodulators may be given safely. Summary: The etiology of persistent joint pain after alphavirus infection is still poorly understood. New diagnostic tools along and evidence-based treatment could significantly improve morbidity and long-term disability.

Original languageEnglish (US)
Article number26
JournalCurrent rheumatology reports
Issue number4
StatePublished - Apr 2021


  • Alphavirus
  • Arthritis
  • Chikungunya
  • Mayaro
  • Ross River
  • Sindbis

ASJC Scopus subject areas

  • Rheumatology


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