Persistent neuroinvasive west nile virus infection in an immunocompromised patient

Robert G. Penn, Jeannette Guarner, James J. Sejvar, Herbert Hartman, Rodney D. McComb, Diana L. Nevins, Julu Bhatnagar, Sherif R. Zaki

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalClinical Infectious Diseases
Volume42
Issue number5
DOIs
StatePublished - Mar 1 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Penn, R. G., Guarner, J., Sejvar, J. J., Hartman, H., McComb, R. D., Nevins, D. L., Bhatnagar, J., & Zaki, S. R. (2006). Persistent neuroinvasive west nile virus infection in an immunocompromised patient. Clinical Infectious Diseases, 42(5), 680-683. https://doi.org/10.1086/500216