Persistent neuroinvasive west nile virus infection in an immunocompromised patient

Robert G. Penn; Jeannette Guarner; James J. Sejvar; Herbert Hartman; Rodney D. McComb; Diana L. Nevins; Julu Bhatnagar; Sherif R. Zaki

doi:10.1086/500216

Persistent neuroinvasive west nile virus infection in an immunocompromised patient

Robert G. Penn, Jeannette Guarner, James J. Sejvar, Herbert Hartman, Rodney D. McComb, Diana L. Nevins, Julu Bhatnagar, Sherif R. Zaki

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

Original language	English (US)
Pages (from-to)	680-683
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	42
Issue number	5
DOIs	https://doi.org/10.1086/500216
State	Published - Mar 1 2006

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/500216

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title = "Persistent neuroinvasive west nile virus infection in an immunocompromised patient",

abstract = "A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.",

author = "Penn, {Robert G.} and Jeannette Guarner and Sejvar, {James J.} and Herbert Hartman and McComb, {Rodney D.} and Nevins, {Diana L.} and Julu Bhatnagar and Zaki, {Sherif R.}",

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AU - Penn, Robert G.

AU - Guarner, Jeannette

AU - Sejvar, James J.

AU - Hartman, Herbert

AU - McComb, Rodney D.

AU - Nevins, Diana L.

AU - Bhatnagar, Julu

AU - Zaki, Sherif R.

PY - 2006/3/1

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N2 - A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

AB - A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

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Persistent neuroinvasive west nile virus infection in an immunocompromised patient

Abstract

ASJC Scopus subject areas

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