PGD synthase and PGD 2 in immune resposne

Myungsoo Joo; Ruxana T. Sadikot

doi:10.1155/2012/503128

PGD synthase and PGD 2 in immune resposne

Myungsoo Joo, Ruxana T. Sadikot

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

PGD2 is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2 to PGD2 by PGD synthases (PGDSs). PGD2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2 provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.

Original language	English (US)
Article number	503128
Journal	Mediators of Inflammation
Volume	2012
DOIs	https://doi.org/10.1155/2012/503128
State	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Immunology
Cell Biology

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AB - PGD2 is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2 to PGD2 by PGD synthases (PGDSs). PGD2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2 provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.

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PGD synthase and PGD 2 in immune resposne

Abstract

ASJC Scopus subject areas

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