PGD synthase and PGD 2 in immune resposne

Myungsoo Joo, Ruxana T. Sadikot

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


PGD2 is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH2, a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH2 to PGD2 by PGD synthases (PGDSs). PGD2 can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD2 provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.

Original languageEnglish (US)
Article number503128
JournalMediators of Inflammation
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology


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