Pharmacogenomics of neurodegenerative diseases: Roles in personalized medicines

Ruby E. Evande, Rinku Dutta, Chalet Tan, Jean L. Grem, Ram I. Mahato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pharmacogenomics is the study of the role of genetic variations in drug response. In the study of pharmacogenomics, one can relate variations in drug exposure and/or drug response (pharmacology) to the variations in genes (genomics). An administered drug may fail to work for one patient, but show the expected result for another. In some cases a drug may work well for a larger group of patients, while causing a subset of patients to experience unexpected or severe side effects. These adverse drug reactions can be harmful and sometimes deadly. Factors such as the environment, diet, age, lifestyle and co-morbid conditions all may influence the individual’s response to drugs. Each is covered in this chapter with an eye towards how best to administer drug to individual patients.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages959-970
Number of pages12
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

Keywords

  • Gene variants
  • Metabolizers
  • Neurodegenerative
  • Pharmacogenomics

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Evande, R. E., Dutta, R., Tan, C., Grem, J. L., & Mahato, R. I. (2016). Pharmacogenomics of neurodegenerative diseases: Roles in personalized medicines. In Neuroimmune Pharmacology (pp. 959-970). Springer International Publishing. https://doi.org/10.1007/978-3-319-44022-4_55