Pharmacogenomics is the study of the role of genetic variations in drug response. In the study of pharmacogenomics, one can relate variations in drug exposure and/or drug response (pharmacology) to the variations in genes (genomics). An administered drug may fail to work for one patient, but show the expected result for another. In some cases a drug may work well for a larger group of patients, while causing a subset of patients to experience unexpected or severe side effects. These adverse drug reactions can be harmful and sometimes deadly. Factors such as the environment, diet, age, lifestyle and co-morbid conditions all may influence the individual’s response to drugs. Each is covered in this chapter with an eye towards how best to administer drug to individual patients.
- Gene variants
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)