Pharmacokinetic study of indicine N-oxide in pediatric cancer patients

Matthew M. Ames, James S. Miser, William A. Smithson, Peter F. Coccia, Carla S. Hughes, Dianne M. Davis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Pharmacokinetics of the experimental antitumor agent indicine N-oxide were investigated in a group of 23 pediatric cancer patients. Plasma elimination of indicine N-oxide was best described by a two-compartment open model. The mean plasma distribution phase half-life, plasma elimination phase half-life, and plasma clearance were 8 min, 84 min, and 62 ml/min/m2 (2.1 ml/min/kg), respectively. One patient with renal impairment had an abnormally long plasma elimination phase half-life (275 min) and reduced plasma clearance (17 ml/min/m2). Plasma elimination phase half-life values increased and plasma clearance values decreased with increasing age of the pediatric patients. Plasma elimination of indicine N-oxide was more rapid in this group of children than in adults who had previously received the drug.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalCancer Chemotherapy and Pharmacology
Volume10
Issue number1
DOIs
StatePublished - Dec 1982

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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