@article{a1e7d4aa3dca4e808917d79db56482df,
title = "Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques",
abstract = "Long-acting antiretrovirals can improve therapy and prevention for HIV-1 infection. Current long-acting cabotegravir (CAB LAP) can be administered every other month. Previously, we demonstrated that a myristoylated CAB prodrug encased in poloxamer 407 provided extended plasma drug concentrations. We now demonstrate that this first-generation nanoformulated prodrug can sustain plasma CAB concentrations above the protein-adjusted 90% inhibitory concentration for 4 months in rhesus macaques. A 2.5-fold extension in CAB half-life and a 1.6-fold increase in area under the concentration-time curve were observed compared with CAB LAP.",
author = "Joellyn McMillan and Adam Szlachetka and Tian Zhou and Brenda Morsey and Benjamin Lamberty and Shannon Callen and Nagsen Gautam and Yazen Alnouti and Benson Edagwa and Gendelman, {Howard E.} and Fox, {Howard S.}",
note = "Funding Information: The authors are grateful to Dr David Ho, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, for permission to use and replot the CAB LAP data from his previously-published work. The authors thank Ms Bhagya Laxmi Dyavar Shetty for her expert technical assistance in UPLC–MS/MS analyses of formulation and plasma drug concentrations. We acknowledge the assistance of the UNMC Comparative Medicine staff, the Nebraska Medicine Pathology/ Microbiology Laboratory and the UNMC Flow Cytometry Core facility. This research was supported by ViiV Healthcare and by National Institutes of Health grants R01 MH104147, P01 DA028555, R01 NS36126, P01 NS31492, 2R01 NS034239, P01 MH64570, P01 NS43985, P30 MH062261, P30 AI078498 and R01 AG043540. Publisher Copyright: {\textcopyright} 2019 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2019",
month = mar,
day = "1",
doi = "10.1097/QAD.0000000000002032",
language = "English (US)",
volume = "33",
pages = "585--588",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}