Abstract
A nanoformulated myristoylated dolutegravir prodrug (NMDTG) was prepared using good laboratory practice protocols. Intramuscular injection of NMDTG (118 ± 8 mg/ml, 25.5 mg of DTG equivalents/kg of body weight) to three rhesus macaques led to plasma DTG levels of 86 ± 12 and 28 ± 1 ng/ml on days 35 and 91, respectively. The NMDTG platform showed no significant adverse events. Further modification may further extend the drug's apparent half-life for human use.
Original language | English (US) |
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Article number | e01316-17 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 62 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2018 |
Keywords
- Dolutegravir
- Long-acting antiretrovirals
- Monkeys
- Nanoformulated antiretrovirals
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases