Pharmacological effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine receptor system

Yuen Sum Lau, Yiu K. Fung

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In mice, chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces an increase in the maximum number of [3H]spiperone binding sites in the striatum. The sensitivity of striatal protein phosphorylation to calcium plus calmodulin is also potentiated in MPTP-treated mice. These observations are associated with an enhancement of apomorphine-induced climbing behavior in the drug-treated animals. The results of this study suggest that in an animal model for Parkinson's disease, MPTP interrupts the dopamine (DA) transmission by chemically denervating the nigrostriatal neurons and through a compensatory mechanism, it increases the number of DA receptors as well as the sensitivity of protein phosphorylation to calcium plus calmodulin in mouse striatum. The latter two events may contribute to the development of DA receptor supersensitivity.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalBrain Research
Volume369
Issue number1-2
DOIs
StatePublished - Mar 26 1986

Keywords

  • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
  • [H]spiperone binding site
  • apomorphine-stimulated-climbing behavior
  • calmodulin-dependent phosphorylation
  • dopamine receptor supersensitivity
  • striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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