Pharmacological treatment of intermittent claudication does not have a significant effect on gait impairments during claudication pain

Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers, Iraklis I. Pipinos, Jason M. Johanning, Nicholas Stergiou

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our previous work has reported no significant differences in gait biomechanics before and after drug interventions when PAD patients walked without pain. However, it is possible that the drugs are more efficacious during gait with pain. Our aim was to use advanced biomechanical analysis to evaluate the effectiveness of these drugs while walking with pain. Initial and absolute claudication distances, joint kinematics, torques, powers, and gait velocity during the presence of pain were measured from 24 patients before and after 12 weeks of treatment with either cilostazol or pentoxifylline. We found no significant improvements after 12 weeks of treatment with either cilostazol or pentoxifylline on the gait biomechanics of PAD patients during pain. Our findings indicate that the medications cilostazol and pentoxifylline have reduced relevance in the care of gait dysfunction even during pain in patients with PAD.

Original languageEnglish (US)
Pages (from-to)184-191
Number of pages8
JournalJournal of applied biomechanics
Volume28
Issue number2
DOIs
StatePublished - May 2012

Keywords

  • Biomechanics
  • Cilostazol
  • Locomotion
  • Pentoxifylline
  • Peripheral arterial disease

ASJC Scopus subject areas

  • General Medicine

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