Pharmacology of NMDA receptors

Daniel T. Monaghan, David E. Jane

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

The discovery of NMDA receptors (NMDARs) was made possible by the synthesis and study of NMDA (Figure 12.1) and various NMDAR antagonists by Jeff Watkins and colleagues. These compounds, most notably (R)-α-aminoadipate ((R)-α-AA) and (R)-2-amino-5-phosphonopentanoate (Figure 12.2), were shown to block neuronal responses to applied NMDA, but not to block responses to kainate or quisqualate. As a result, NMDARs were shown to represent a distinct subpopulation of excitatory amino acid receptors.

Original languageEnglish (US)
Title of host publicationBiology of the NMDA Receptor
PublisherCRC Press
Pages257-281
Number of pages25
ISBN (Electronic)9781420044157
ISBN (Print)9781420044140
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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