Pharmacology of NMDA receptors

Daniel T. Monaghan; David E. Jane

Pharmacology of NMDA receptors

Daniel T. Monaghan, David E. Jane

Pharmacology & Experimental Neuroscience (PEN)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

The discovery of NMDA receptors (NMDARs) was made possible by the synthesis and study of NMDA (Figure 12.1) and various NMDAR antagonists by Jeff Watkins and colleagues. These compounds, most notably (R)-α-aminoadipate ((R)-α-AA) and (R)-2-amino-5-phosphonopentanoate (Figure 12.2), were shown to block neuronal responses to applied NMDA, but not to block responses to kainate or quisqualate. As a result, NMDARs were shown to represent a distinct subpopulation of excitatory amino acid receptors.

Original language	English (US)
Title of host publication	Biology of the NMDA Receptor
Publisher	CRC Press
Pages	257-281
Number of pages	25
ISBN (Electronic)	9781420044157
ISBN (Print)	9781420044140
State	Published - Jan 1 2008

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Medicine

Cite this

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AB - The discovery of NMDA receptors (NMDARs) was made possible by the synthesis and study of NMDA (Figure 12.1) and various NMDAR antagonists by Jeff Watkins and colleagues. These compounds, most notably (R)-α-aminoadipate ((R)-α-AA) and (R)-2-amino-5-phosphonopentanoate (Figure 12.2), were shown to block neuronal responses to applied NMDA, but not to block responses to kainate or quisqualate. As a result, NMDARs were shown to represent a distinct subpopulation of excitatory amino acid receptors.

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SP - 257

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BT - Biology of the NMDA Receptor

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ER -

Pharmacology of NMDA receptors

Abstract

ASJC Scopus subject areas

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