Phenacetin abuse and renal pelvic carcinoma

U. Bengtsson; L. Angervall; S. Johansson; L. Wahlgvist

Phenacetin abuse and renal pelvic carcinoma

U. Bengtsson, L. Angervall, S. Johansson, L. Wahlgvist

Research output: Contribution to journal › Article › peer-review

Abstract

This work is a review of 62 patients with abuse of phenacetin containing drugs and uroepithelial tumors of the renal pelvis, all of them carcinomas. Most of the patients had a preexisting nephropathy with papillary necrosis as a prominent feature. Renal impairment contributed to the poor prognosis. On the basis of present knowledge of urinary tract carcinogens and phenacetin metabolites, it is assumed that phenacetin is the crucial factor for development of the tumours.

Original language	English (US)
Pages (from-to)	290-294
Number of pages	5
Journal	International Journal of Clinical Pharmacology Therapy and Toxicology
Volume	12
Issue number	1-2
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

Cite this

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abstract = "This work is a review of 62 patients with abuse of phenacetin containing drugs and uroepithelial tumors of the renal pelvis, all of them carcinomas. Most of the patients had a preexisting nephropathy with papillary necrosis as a prominent feature. Renal impairment contributed to the poor prognosis. On the basis of present knowledge of urinary tract carcinogens and phenacetin metabolites, it is assumed that phenacetin is the crucial factor for development of the tumours.",

author = "U. Bengtsson and L. Angervall and S. Johansson and L. Wahlgvist",

year = "1975",

language = "English (US)",

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AU - Bengtsson, U.

AU - Angervall, L.

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AU - Wahlgvist, L.

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N2 - This work is a review of 62 patients with abuse of phenacetin containing drugs and uroepithelial tumors of the renal pelvis, all of them carcinomas. Most of the patients had a preexisting nephropathy with papillary necrosis as a prominent feature. Renal impairment contributed to the poor prognosis. On the basis of present knowledge of urinary tract carcinogens and phenacetin metabolites, it is assumed that phenacetin is the crucial factor for development of the tumours.

AB - This work is a review of 62 patients with abuse of phenacetin containing drugs and uroepithelial tumors of the renal pelvis, all of them carcinomas. Most of the patients had a preexisting nephropathy with papillary necrosis as a prominent feature. Renal impairment contributed to the poor prognosis. On the basis of present knowledge of urinary tract carcinogens and phenacetin metabolites, it is assumed that phenacetin is the crucial factor for development of the tumours.

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Phenacetin abuse and renal pelvic carcinoma

Abstract

ASJC Scopus subject areas

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