Phenobarbital-Induced Fatty Livers in the Rat

M. F. Sorrell; D. J. Tuma; J. K. Noffsinger; A. J. Barak

doi:10.3181/00379727-143-37425

Phenobarbital-Induced Fatty Livers in the Rat

M. F. Sorrell, D. J. Tuma, J. K. Noffsinger, A. J. Barak

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Administration of phenobarbital to rats fed a standard laboratory diet or 6 different synthetic diets produced elevated levels of triglyceride, phospholipid and total cholesterol in the livers of these animals. By varying the choline, fat, and protein constituents in these diets it appears that choline and fat content are factors influencing the amount of triglyceride accumulating in livers as a result of phenobarbital administration. These dietary factors, however, did not appear to regulate the manner in which phenobarbital elevated phospholipid and total cholesterol levels.

Original language	English (US)
Pages (from-to)	839-843
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	3
DOIs	https://doi.org/10.3181/00379727-143-37425
State	Published - Jul 1973

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "Administration of phenobarbital to rats fed a standard laboratory diet or 6 different synthetic diets produced elevated levels of triglyceride, phospholipid and total cholesterol in the livers of these animals. By varying the choline, fat, and protein constituents in these diets it appears that choline and fat content are factors influencing the amount of triglyceride accumulating in livers as a result of phenobarbital administration. These dietary factors, however, did not appear to regulate the manner in which phenobarbital elevated phospholipid and total cholesterol levels.",

author = "Sorrell, {M. F.} and Tuma, {D. J.} and Noffsinger, {J. K.} and Barak, {A. J.}",

note = "Funding Information: The investigation was supported in part by the Veterans Administration project No. 0804–04. ",

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AU - Sorrell, M. F.

AU - Tuma, D. J.

AU - Noffsinger, J. K.

AU - Barak, A. J.

N1 - Funding Information: The investigation was supported in part by the Veterans Administration project No. 0804–04.

PY - 1973/7

Y1 - 1973/7

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AB - Administration of phenobarbital to rats fed a standard laboratory diet or 6 different synthetic diets produced elevated levels of triglyceride, phospholipid and total cholesterol in the livers of these animals. By varying the choline, fat, and protein constituents in these diets it appears that choline and fat content are factors influencing the amount of triglyceride accumulating in livers as a result of phenobarbital administration. These dietary factors, however, did not appear to regulate the manner in which phenobarbital elevated phospholipid and total cholesterol levels.

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Phenobarbital-Induced Fatty Livers in the Rat

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