Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia

Laura K. Smoyer, Douglas R. Dorer, Kenneth W. Nickerson, Alan C. Christensen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The Triplo-lethal locus (Tpl) of Drosophila is both triplo-lethal and haploinsufficient, but the function of the locus is unknown. We have examined Tpl-aneuploid embryos and find that, in both trisomics and monosomics, the midgut shows extensive cell death and the tracheae are abnormal. Shortly thereafter, all tissues die. PCR-based genotyping of individual embryos and larvae show that this phenotype occurs in the trisomics after hatching and in the monosomics before hatching. Weak alleles of the interacting gene Su(Tpl) delay the death of Tpl trisomics, but they still show the same tracheal and midgut phenotypes before dying. Hyperoxia (45% oxygen) partially suppresses the phenotype of Tpl aneuploids, even though the use of a hypoxia reporter strain shows that dying Tpl aneuploids are not hypoxic. This is the first report of a phenotype associated with the Tpl locus and the first report of an environmental condition that suppresses the phenotype.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalGenetical Research
Issue number3
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Genetics


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