Phenotype/genotype correlations in the ultrastructure of monogenetic glomerular diseases

Helen Liapis, K. Foster, E. Theodoropoulou, G. Monga, S. Pizzolitto, G. Mazzucco

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Electron microscopy defined classic patterns of hereditary glomerular disease long before genetics revealed an underlying specific mutation. Genetic analysis is now easier to perform in clinical practice but an earlier optimism that genetics would predict disease severity and phenotype is challenged. The classic paradigm is Alport nephritis in which only a subset of mutations may predict glomerular abnormalities and disease severity. Interpretation of ultrastructural pathology of monogenetic diseases like Alport nephritis is complicated when the proband is the first family member to be diagnosed or there is discrepancy between clinical presentation and ultrastructural changes. In this review the authors have selected a dozen cases representative of common monogenetic glomerular diseases as a platform to discuss the utility of diagnostic electron microscopy in the era of molecular genetics. The emphasis is on genotype/glomerular phenotype correlations.

Original languageEnglish (US)
Pages (from-to)181-197
Number of pages17
JournalUltrastructural Pathology
Volume28
Issue number4
DOIs
StatePublished - Jul 2004

Keywords

  • Electron microscopy
  • Glomerular disease
  • Hereditary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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