Philadelphia chromosome positive childhood acute lymphoblastic leukemia

J. R. Priest, L. L. Robison, R. W. McKenna, L. L. Lindquist, P. I. Warkentin, T. W. LeBien, W. G. Woods, J. H. Kersey, P. F. Coccia, M. E. Nesbit

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

In a 3-yr period, the Philadelphia (Ph1) was found in 4 of 43 children with acute lymphoblastic leukemia (ALL) in whom chromosomes were studied at diagnosis. The clinical, morphological, cytochemical, and immunologic findings in the Ph1-positive (Ph1+) cases were consistent with typical childhood ALL, indicating that identification of cases requires chromosome studies. A review of all reported cases of Ph1+ childhood ALL shows that Ph1+ patients are older and have higher initial platelet and white blood cell counts (WBC) than most children with ALL. However, a life table comparison between the reported cases of pH1+ ALL in children and randomly selected age-, sex-, and WBC-matched controls with ALL shows the duration on first marrow remission to be significantly shorter (p<0.02) for the Ph1+ cases. Ph1+ ALL is a distinct subtype of childhood ALL that is not rare and can be identified only by cytogenetic studies. The prognosis is poor. Cytogenetic studies should be done prospectively in a large group of children with ALL to define further this subgroup of patients and to confirm the findings of this retrospective analysis.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalBlood
Volume56
Issue number1
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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