Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

Narendra Thapa, Suyong Choi, Xiaojun Tan, Thomas Wise, Richard A. Anderson

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Background: PIP2 generated by PIPKI family members regulates many cellular functions, and PIP2 is a PI3K substrate. Results: Loss of PIPKIγ or PIPKIγi2 impaired Akt activation. PIPKIγi2 and Src activate Akt and anchorage-independent growth. Conclusion: PI3K/Akt signaling is regulated by coupling with PIPKIγ. Significance: The coupling of PIPKIγ and PI3K indicates a mechanism for Akt activation that enhances oncogenic growth.

Original languageEnglish (US)
Pages (from-to)18843-18854
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number30
DOIs
StatePublished - Jul 24 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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