Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

Narendra Thapa; Suyong Choi; Xiaojun Tan; Thomas Wise; Richard A. Anderson

doi:10.1074/jbc.M114.596742

Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

Narendra Thapa, Suyong Choi, Xiaojun Tan, Thomas Wise, Richard A. Anderson

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Background: PIP₂ generated by PIPKI family members regulates many cellular functions, and PIP₂ is a PI3K substrate. Results: Loss of PIPKIγ or PIPKIγi2 impaired Akt activation. PIPKIγi2 and Src activate Akt and anchorage-independent growth. Conclusion: PI3K/Akt signaling is regulated by coupling with PIPKIγ. Significance: The coupling of PIPKIγ and PI3K indicates a mechanism for Akt activation that enhances oncogenic growth.

Original language	English (US)
Pages (from-to)	18843-18854
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M114.596742
State	Published - Jul 24 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth",

abstract = "Background: PIP2 generated by PIPKI family members regulates many cellular functions, and PIP2 is a PI3K substrate. Results: Loss of PIPKIγ or PIPKIγi2 impaired Akt activation. PIPKIγi2 and Src activate Akt and anchorage-independent growth. Conclusion: PI3K/Akt signaling is regulated by coupling with PIPKIγ. Significance: The coupling of PIPKIγ and PI3K indicates a mechanism for Akt activation that enhances oncogenic growth.",

author = "Narendra Thapa and Suyong Choi and Xiaojun Tan and Thomas Wise and Anderson, {Richard A.}",

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T1 - Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

AU - Thapa, Narendra

AU - Choi, Suyong

AU - Tan, Xiaojun

AU - Wise, Thomas

AU - Anderson, Richard A.

PY - 2015/7/24

Y1 - 2015/7/24

N2 - Background: PIP2 generated by PIPKI family members regulates many cellular functions, and PIP2 is a PI3K substrate. Results: Loss of PIPKIγ or PIPKIγi2 impaired Akt activation. PIPKIγi2 and Src activate Akt and anchorage-independent growth. Conclusion: PI3K/Akt signaling is regulated by coupling with PIPKIγ. Significance: The coupling of PIPKIγ and PI3K indicates a mechanism for Akt activation that enhances oncogenic growth.

AB - Background: PIP2 generated by PIPKI family members regulates many cellular functions, and PIP2 is a PI3K substrate. Results: Loss of PIPKIγ or PIPKIγi2 impaired Akt activation. PIPKIγi2 and Src activate Akt and anchorage-independent growth. Conclusion: PI3K/Akt signaling is regulated by coupling with PIPKIγ. Significance: The coupling of PIPKIγ and PI3K indicates a mechanism for Akt activation that enhances oncogenic growth.

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Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth

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