TY - JOUR
T1 - Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases
AU - Choi, Suyong
AU - Houdek, Xander
AU - Anderson, Richard A.
N1 - Funding Information:
Due to space constraints some relevant studies may not have been referenced. This work was supported by NIH ( RO1 144-AAA7837 and RO1 144-AAC2557 ) grants to RAA. The authors have declared no conflict of interest.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has been focused on investigations of individual PIPKs and their underlying molecular regulation of cellular processes. Here, we will discuss recent advances in the study of how PIPKs control specific cellular events through assembly and regulation of PI4,5P2 effectors that mediate specific cellular processes. A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy.
AB - Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has been focused on investigations of individual PIPKs and their underlying molecular regulation of cellular processes. Here, we will discuss recent advances in the study of how PIPKs control specific cellular events through assembly and regulation of PI4,5P2 effectors that mediate specific cellular processes. A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy.
KW - Autophagy
KW - Phosphatidylinositol 4,5-bisphosphate
KW - Phosphatidylinositol phosphate kinase
KW - Phosphoinositide
KW - Phosphoinositide 3-kinase
KW - Signal transduction
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U2 - 10.1016/j.jbior.2018.02.003
DO - 10.1016/j.jbior.2018.02.003
M3 - Article
C2 - 29472147
AN - SCOPUS:85042183802
VL - 68
SP - 31
EP - 38
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
SN - 2212-4926
ER -