Phospholipid effects on the rat lens transport systems

Peter F. Kador; Jin H. Kinoshita

doi:10.1016/0014-4835(78)90100-8

Phospholipid effects on the rat lens transport systems

Peter F. Kador, Jin H. Kinoshita

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The in vitro effects of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, sphingomyelin, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl serine, glycerophosphoryl choline, and phosphatidic acid on rubidium uptake and amino acid transport of rat lens are presented. None of these lipids affected the rubidium uptake mechanism; however, a large increase in the apparent leak-out of rubidium was observed with lysophosphatidyl choline. Lysophosphatidyl choline also inhibited all of the amino acid transport systems (A, ASC, L, Gly, Ly and β) as well as the uptake of inositol.

Original language	English (US)
Pages (from-to)	657-665
Number of pages	9
Journal	Experimental Eye Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/0014-4835(78)90100-8
State	Published - Jun 1978
Externally published	Yes

Keywords

amino acid transport inhibition
cataract
lysophosphatidyl choline
phospholipids
rubidium transport

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(78)90100-8

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title = "Phospholipid effects on the rat lens transport systems",

abstract = "The in vitro effects of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, sphingomyelin, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl serine, glycerophosphoryl choline, and phosphatidic acid on rubidium uptake and amino acid transport of rat lens are presented. None of these lipids affected the rubidium uptake mechanism; however, a large increase in the apparent leak-out of rubidium was observed with lysophosphatidyl choline. Lysophosphatidyl choline also inhibited all of the amino acid transport systems (A, ASC, L, Gly, Ly and β) as well as the uptake of inositol.",

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AU - Kador, Peter F.

AU - Kinoshita, Jin H.

PY - 1978/6

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AB - The in vitro effects of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, sphingomyelin, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl serine, glycerophosphoryl choline, and phosphatidic acid on rubidium uptake and amino acid transport of rat lens are presented. None of these lipids affected the rubidium uptake mechanism; however, a large increase in the apparent leak-out of rubidium was observed with lysophosphatidyl choline. Lysophosphatidyl choline also inhibited all of the amino acid transport systems (A, ASC, L, Gly, Ly and β) as well as the uptake of inositol.

KW - amino acid transport inhibition

KW - cataract

KW - lysophosphatidyl choline

KW - phospholipids

KW - rubidium transport

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Phospholipid effects on the rat lens transport systems

Abstract

Keywords

ASJC Scopus subject areas

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