Phospholipid effects on the rat lens transport systems

Peter F. Kador, Jin H. Kinoshita

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The in vitro effects of phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, sphingomyelin, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl serine, glycerophosphoryl choline, and phosphatidic acid on rubidium uptake and amino acid transport of rat lens are presented. None of these lipids affected the rubidium uptake mechanism; however, a large increase in the apparent leak-out of rubidium was observed with lysophosphatidyl choline. Lysophosphatidyl choline also inhibited all of the amino acid transport systems (A, ASC, L, Gly, Ly and β) as well as the uptake of inositol.

Original languageEnglish (US)
Pages (from-to)657-665
Number of pages9
JournalExperimental Eye Research
Volume26
Issue number6
DOIs
StatePublished - Jun 1978

Keywords

  • amino acid transport inhibition
  • cataract
  • lysophosphatidyl choline
  • phospholipids
  • rubidium transport

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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