PHOTOCHEMICAL COUPLING OF BENZO[a]PYRENE WITH 1‐METHYLCYTOSINE; PHOTOENHANCEMENT OF CARCINOGENICITY

E. CAVALIERI, M. CALVIN

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Abstract— Irradiation of the carcinogenic benzo[a]pyrene(I) with 1‐methylcytosine hydro‐chloride(II) (molar ratio 1:10) at 3500 Å in methanol‐acetone produces the 6‐(1‐methylcytos‐5‐yl)‐benzo[a]pyrene(III). The structure of the product shows the hydrocarbon bound through the most active 6‐carbon atom to the nucleophilic 5‐position of the base. In the second part, the possibility of observing carcinogenic effects on the mouse skin from non‐carcinogenic hydrocarbons under the action of u.v. light is investigated. Both experiments provide evidence that the 4,5‐double bond (K region) of I presumably does not play a role in triggering the cancer process.

Original languageEnglish (US)
Pages (from-to)641-653
Number of pages13
JournalPhotochemistry and Photobiology
Volume14
Issue number5
DOIs
StatePublished - Nov 1971

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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