Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

H. Kasai, Z. Yamaizumi, F. Yamamoto, T. Bessho, S. Nishimura, M. Berger, J. Cadet

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

Original languageEnglish (US)
Pages (from-to)181-182
Number of pages2
JournalNucleic acids symposium series
Issue number27
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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