Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

H. Kasai; Z. Yamaizumi; F. Yamamoto; T. Bessho; S. Nishimura; M. Berger; J. Cadet

Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

H. Kasai, Z. Yamaizumi, F. Yamamoto, T. Bessho, S. Nishimura, M. Berger, J. Cadet

Research output: Contribution to journal › Article › peer-review

Abstract

Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

Original language	English (US)
Pages (from-to)	181-182
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	27
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.",

abstract = "Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.",

author = "H. Kasai and Z. Yamaizumi and F. Yamamoto and T. Bessho and S. Nishimura and M. Berger and J. Cadet",

year = "1992",

language = "English (US)",

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journal = "Nucleic acids symposium series",

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T1 - Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

AU - Kasai, H.

AU - Yamaizumi, Z.

AU - Yamamoto, F.

AU - Bessho, T.

AU - Nishimura, S.

AU - Berger, M.

AU - Cadet, J.

PY - 1992

Y1 - 1992

N2 - Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

AB - Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

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AN - SCOPUS:0027031353

SN - 0261-3166

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IS - 27

ER -

Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

Abstract

ASJC Scopus subject areas

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