Physiological Approach for Coronary Artery Bifurcation Disease: Position Statement by Korean, Japanese, and European Bifurcation Clubs

Hak Seung Lee, Ung Kim, Seokhun Yang, Yoshinobu Murasato, Yves Louvard, Young Bin Song, Takashi Kubo, Thomas W. Johnson, Soon Jun Hong, Hiroyuki Omori, Manuel Pan, Joon Hyung Doh, Yoshihisa Kinoshita, Adrian P. Banning, Chang Wook Nam, Junya Shite, Thierry Lefèvre, Hyeon Cheol Gwon, Yutaka Hikichi, Yiannis S. ChatzizisisJens Flensted Lassen, Goran Stankovic, Bon Kwon Koo

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Coronary artery bifurcation lesions are frequently encountered in cardiac catheterization laboratories and are associated with more complex procedures and worse clinical outcomes than nonbifurcation lesions. Therefore, anatomical and physiological assessment of bifurcation lesions before, during, and after percutaneous coronary intervention is of paramount clinical importance. Physiological assessment can help interventionalists appreciate the hemodynamic significance of coronary artery disease and guide ischemia-directed revascularization. However, it is important to understand that the physiological approach for bifurcation disease is more important than simply using physiological indexes for its assessment. This joint consensus document by the Korean, Japanese, and European bifurcation clubs presents the concept of a physiological approach for coronary bifurcation lesions, as well as current knowledge, practical tips, pitfalls, and future directions of applying physiological indexes in bifurcation percutaneous coronary intervention. This document aims to guide interventionalists in performing appropriate physiology-based assessments and treatment decisions for coronary bifurcation lesions.

Original languageEnglish (US)
Pages (from-to)1297-1309
Number of pages13
JournalJACC: Cardiovascular Interventions
Issue number13
StatePublished - Jul 11 2022


  • bifurcation
  • coronary artery
  • physiological indexes
  • physiology
  • revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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