Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

Shikha Kumari, Krishnaiah Maddeboina, Rinda Devi Bachu, Sai H.S. Boddu, Paul C. Trippier, Amit K. Tiwari

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively worsens with time. Clinical options are limited and only provide symptomatic relief to AD patients. The search for effective anti-AD compounds is ongoing with a few already in Phase III clinical trials, yet to be approved. Heterocycles containing nitrogen are important to biological processes owing to their abundance in nature, their function as subunits of biological molecules and/or macromolecular structures, and their biological activities. The present review discusses previously used strategies, SAR, relevant in vitro and in vivo studies, and success stories of nitrogen-containing heterocyclic compounds in AD drug discovery. Also, we propose strategies for designing and developing novel potent anti-AD small molecules that can be used as treatments for AD.

Original languageEnglish (US)
Article number103322
JournalDrug Discovery Today
Issue number10
StatePublished - Oct 2022


  • Alzheimer's disease
  • Drug discovery
  • Multi-target directed ligands
  • Nitrogen heterocycles

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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