PKCα and PKCδ: Friends and Rivals

Jennifer D. Black, Trisiani Affandi, Adrian R. Black, Mary E. Reyland

Research output: Contribution to journalReview articlepeer-review

Abstract

PKC comprises a large family of serine/threonine kinases that share a requirement for allosteric activation by lipids. While PKC isoforms have significant homology, functional divergence is evident among subfamilies and between individual PKC isoforms within a subfamily. Here, we highlight these differences by comparing the regulation and function of representative PKC isoforms from the conventional (PKCα) and novel (PKCδ) subfamilies. We discuss how unique structural features of PKCα and PKCδ underlie differences in activation and highlight the similar, divergent, and even opposing biological functions of these kinases. We also consider how PKCα and PKCδ can contribute to pathophysiological conditions and discuss challenges to targeting these kinases therapeutically.

Original languageEnglish (US)
Article number102194
JournalJournal of Biological Chemistry
Volume298
Issue number8
DOIs
StatePublished - Aug 2022

Keywords

  • apoptosis
  • cancer
  • cell cycle
  • differentiation
  • migration
  • PKC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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