Plant targets for Pseudomonas syringae type III effectors: Virulence targets or guarded decoys?

Anna Block; James R. Alfano

doi:10.1016/j.mib.2010.12.011

Plant targets for Pseudomonas syringae type III effectors: Virulence targets or guarded decoys?

Anna Block, James R. Alfano

Research output: Contribution to journal › Review article › peer-review

175 Scopus citations

Abstract

The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities.

Original language	English (US)
Pages (from-to)	39-46
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.mib.2010.12.011
State	Published - Feb 2011
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.1016/j.mib.2010.12.011

Cite this

@article{6769df1f2db44833bbe83da2def245cf,

title = "Plant targets for Pseudomonas syringae type III effectors: Virulence targets or guarded decoys?",

abstract = "The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities.",

author = "Anna Block and Alfano, {James R.}",

note = "Funding Information: Research in the Alfano laboratory is currently being supported by grants from the National Science Foundation (Award No. MCB-0940177 ), United States Department of Agriculture ( 2007-35319-18336 ), and the National Institutes of Health (Award No. 1R01AI069146-01A2 ) and funds from the Center for Plant Science Innovation at the University of Nebraska .",

year = "2011",

month = feb,

doi = "10.1016/j.mib.2010.12.011",

language = "English (US)",

volume = "14",

pages = "39--46",

journal = "Current Opinion in Microbiology",

issn = "1369-5274",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Plant targets for Pseudomonas syringae type III effectors

T2 - Virulence targets or guarded decoys?

AU - Block, Anna

AU - Alfano, James R.

N1 - Funding Information: Research in the Alfano laboratory is currently being supported by grants from the National Science Foundation (Award No. MCB-0940177 ), United States Department of Agriculture ( 2007-35319-18336 ), and the National Institutes of Health (Award No. 1R01AI069146-01A2 ) and funds from the Center for Plant Science Innovation at the University of Nebraska .

PY - 2011/2

Y1 - 2011/2

N2 - The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities.

AB - The phytopathogenic bacterium Pseudomonas syringae can suppress both pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) by the injection of type III effector (T3E) proteins into host cells. T3Es achieve immune suppression using a variety of strategies including interference with immune receptor signaling, blocking RNA pathways and vesicle trafficking, and altering organelle function. T3Es can be recognized indirectly by resistance proteins monitoring specific T3E targets resulting in ETI. It is presently unclear whether the monitored targets represent bona fide virulence targets or guarded decoys. Extensive overlap between PTI and ETI signaling suggests that T3Es may suppress both pathways through common targets and by possessing multiple activities.

UR - http://www.scopus.com/inward/record.url?scp=79551688310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551688310&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2010.12.011

DO - 10.1016/j.mib.2010.12.011

M3 - Review article

C2 - 21227738

AN - SCOPUS:79551688310

SN - 1369-5274

VL - 14

SP - 39

EP - 46

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - 1

ER -

Plant targets for Pseudomonas syringae type III effectors: Virulence targets or guarded decoys?

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this