Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA

Marie Feser; Lezlie A. Derber; Kevin D. Deane; Dennis C. Lezotte; Michael H. Weisman; Jane H. Buckner; Ted Mikuls; James O'Dell; Peter K. Gregersen; V. Michael Holers; Jill M. Norris

doi:10.3899/jrheum.080764

Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA

Marie Feser, Lezlie A. Derber, Kevin D. Deane, Dennis C. Lezotte, Michael H. Weisman, Jane H. Buckner, Ted Mikuls, James O'Dell, Peter K. Gregersen, V. Michael Holers, Jill M. Norris

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Abstract

Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. The Journal of Rheumatology

Original language	English (US)
Pages (from-to)	943-946
Number of pages	4
Journal	Journal of Rheumatology
Volume	36
Issue number	5
DOIs	https://doi.org/10.3899/jrheum.080764
State	Published - May 2009

Keywords

Autoantibodies
Rheumatoid arthritis
Vitamin D

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

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10.3899/jrheum.080764

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Feser, M., Derber, L. A., Deane, K. D., Lezotte, D. C., Weisman, M. H., Buckner, J. H., Mikuls, T., O'Dell, J., Gregersen, P. K., Holers, V. M., & Norris, J. M. (2009). Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. Journal of Rheumatology, 36(5), 943-946. https://doi.org/10.3899/jrheum.080764

Feser, M, Derber, LA, Deane, KD, Lezotte, DC, Weisman, MH, Buckner, JH, Mikuls, T , O'Dell, J, Gregersen, PK, Holers, VM & Norris, JM 2009, 'Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA', Journal of Rheumatology, vol. 36, no. 5, pp. 943-946. https://doi.org/10.3899/jrheum.080764

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title = "Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA",

abstract = "Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. The Journal of Rheumatology",

keywords = "Autoantibodies, Rheumatoid arthritis, Vitamin D",

author = "Marie Feser and Derber, {Lezlie A.} and Deane, {Kevin D.} and Lezotte, {Dennis C.} and Weisman, {Michael H.} and Buckner, {Jane H.} and Ted Mikuls and James O'Dell and Gregersen, {Peter K.} and Holers, {V. Michael} and Norris, {Jill M.}",

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doi = "10.3899/jrheum.080764",

language = "English (US)",

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AU - Feser, Marie

AU - Derber, Lezlie A.

AU - Deane, Kevin D.

AU - Lezotte, Dennis C.

AU - Weisman, Michael H.

AU - Buckner, Jane H.

AU - Mikuls, Ted

AU - O'Dell, James

AU - Gregersen, Peter K.

AU - Holers, V. Michael

AU - Norris, Jill M.

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N2 - Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. The Journal of Rheumatology

AB - Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. The Journal of Rheumatology

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Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA

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