Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA

Marie Feser, Lezlie A. Derber, Kevin D. Deane, Dennis C. Lezotte, Michael H. Weisman, Jane H. Buckner, Ted Mikuls, James O'Dell, Peter K. Gregersen, V. Michael Holers, Jill M. Norris

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA. Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort. Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63). Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)943-946
Number of pages4
JournalJournal of Rheumatology
Volume36
Issue number5
DOIs
StatePublished - May 1 2009

Keywords

  • Autoantibodies
  • Rheumatoid arthritis
  • Vitamin D

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Feser, M., Derber, L. A., Deane, K. D., Lezotte, D. C., Weisman, M. H., Buckner, J. H., Mikuls, T., O'Dell, J., Gregersen, P. K., Holers, V. M., & Norris, J. M. (2009). Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. Journal of Rheumatology, 36(5), 943-946. https://doi.org/10.3899/jrheum.080764