Plasma exudation in conscious dogs with experimental heart failure

I. Rubinstein, G. Müns, I. H. Zucker

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The purpose of this study was to determine the effects of bradykinin (BK), substance P (SP) and histamine on plasma exudation in the skin of conscious dogs with and without pacing-induced heart failure. We also determined the role tissue angiotensin I-converting enzyme (ACE) and neutral endopeptidase (NEP) play in modulating these responses. We found that intradermal injection of BK, SP and histamine induced a significant, concentration-dependent Evans blue exudation in normal dogs (p<0.05). Bradykinin-induced responses were significantly potentiated by captopril (p<0.05). In contrast, phosphoramidon potentiated BK-induced responses only at low concentrations of BK. Both captopril and phosphoramidon had no significant effects on SP-and histamine-induced Evans blue exudation. BK- and SP-induced responses were significantly attenuated, whereas histamine-induced Evans blue exudation was significantly potentiated in dogs with heart failure. We conclude that heart failure is associated with attenuation of BK- and SP-, but not histamine-induced plasma exudation in the peripheral microcirculation and that these responses are not modulated by tissue ACE and NEP.

Original languageEnglish (US)
Pages (from-to)487-498
Number of pages12
JournalBasic research in cardiology
Issue number5
StatePublished - Sep 1994


  • Bradykinin
  • angiotensin I-converting enzyme
  • histamine
  • neutral endopeptidase
  • substance P

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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