Plasma levels of soluble CD14 and tumor necrosis factor-α type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection

Lisa A. Ryan, Jialin Zheng, Michelle Brester, Daryl Bohac, Francis Hahn, James Anderson, Winai Ratanasuwan, Howard E. Gendelman, Susan Swindells

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean ± SEM CD4+ T lymphocyte count and virus load for all patients were 237 ± 41 cells/mm3 and 77,091 ± 195,372 HIV-1 RNA copies/mL, respectively. Levels of soluble tumor necrosis factor-α type II receptor (sTNF-RII) and soluble CD14 (sCD14) were measured in plasma by ELISA and were correlated with results from neuropsychological, magnetic resonance imaging, and magnetic resonance spectroscopy tests. Plasma sCD14 and sTNF-RII levels were elevated in subjects with cognitive impairment and in those with brain atrophy. Furthermore, both factors were correlated with spectroscopic choline:creatine ratios. These findings support the idea that peripheral immune responses are linked to cognitive dysfunction during advanced HIV-1 disease.

Original languageEnglish (US)
Pages (from-to)699-706
Number of pages8
JournalJournal of Infectious Diseases
Volume184
Issue number6
DOIs
StatePublished - Sep 15 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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