TY - JOUR
T1 - Plasma proteomic profiling in HIV-1 infected methamphetamine abusers
AU - Pottiez, Gwenael
AU - Jagadish, Teena
AU - Yu, Fang
AU - Letendre, Scott
AU - Ellis, Ronald
AU - Duarte, Nichole A.
AU - Grant, Igor
AU - Gendelman, Howard Eliot
AU - Fox, Howard S
AU - Ciborowski, Pawel S
PY - 2012/2/16
Y1 - 2012/2/16
N2 - We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.
AB - We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.
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U2 - 10.1371/journal.pone.0031031
DO - 10.1371/journal.pone.0031031
M3 - Article
C2 - 22359561
AN - SCOPUS:84857128392
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 2
M1 - e31031
ER -