Plasma proteomic profiling in HIV-1 infected methamphetamine abusers

Gwenael Pottiez, Teena Jagadish, Fang Yu, Scott Letendre, Ronald Ellis, Nichole A. Duarte, Igor Grant, Howard Eliot Gendelman, Howard S Fox, Pawel S Ciborowski

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.

Original languageEnglish (US)
Article numbere31031
JournalPloS one
Volume7
Issue number2
DOIs
StatePublished - Feb 16 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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