Platelet-derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization

Mohammad Ali Sadiq; Mostafa Hanout; Salman Sarwar; Muhammad Hassan; Aniruddha Agarwal; Yasir Jamal Sepah; Diana V. Do; Quan Dong Nguyen

doi:10.1159/000438953

Platelet-derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization

Mohammad Ali Sadiq, Mostafa Hanout, Salman Sarwar, Muhammad Hassan, Aniruddha Agarwal, Yasir Jamal Sepah, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly neovascular AMD, has become more exciting due to agents like PDGF antagonists.

Original language	English (US)
Pages (from-to)	310-316
Number of pages	7
Journal	Developments in Ophthalmology
Volume	55
DOIs	https://doi.org/10.1159/000438953
State	Published - 2015

ASJC Scopus subject areas

Ophthalmology

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10.1159/000438953

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title = "Platelet-derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization",

abstract = "Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly neovascular AMD, has become more exciting due to agents like PDGF antagonists.",

author = "Sadiq, {Mohammad Ali} and Mostafa Hanout and Salman Sarwar and Muhammad Hassan and Aniruddha Agarwal and Sepah, {Yasir Jamal} and Do, {Diana V.} and Nguyen, {Quan Dong}",

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T1 - Platelet-derived growth factor inhibitors

T2 - A potential therapeutic approach for ocular neovascularization

AU - Sadiq, Mohammad Ali

AU - Hanout, Mostafa

AU - Sarwar, Salman

AU - Hassan, Muhammad

AU - Agarwal, Aniruddha

AU - Sepah, Yasir Jamal

AU - Do, Diana V.

AU - Nguyen, Quan Dong

PY - 2015

Y1 - 2015

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AB - Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly neovascular AMD, has become more exciting due to agents like PDGF antagonists.

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Platelet-derived growth factor inhibitors: A potential therapeutic approach for ocular neovascularization

Abstract

ASJC Scopus subject areas

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