Platelet derived wound healing factors (PDWHF) accelerate and augment wound healing angiogenesis in the rat

G. D. Phillips, A. M. Stone, R. A. Whitehead, D. R. Knighton

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The object of this study was to determine the effect of PDWHF on wound healing angiogenesis. Sponges saturated with PDWHF were implanted in rats. Six hours to 14 days post-implantation, vascular corrosion casts were prepared and examined by SEM. Leukocyte margination and angiogenesis was accelerated by 24-48 hours. Vessel number was also greater than in the controls. Another series of PDWHF treated sponges were implanted. Fourteen days later the vasculature was perfused with Evans blue. Sponges were homogenized, and absorbance of the supernatants was determined. Absorbances of PDWHF supernatants was 2X greater than controls. PDWHF enhanced wound healing angiogenesis in the rat.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalIn Vivo
Volume8
Issue number2
StatePublished - 1994

Keywords

  • angiogenesis
  • endothelial cells
  • scanning electron microscopy
  • vascular corrosion casts
  • wound healing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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