Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms

Dirk Bausch, Mari Mino-Kenudson, Carlos Fernández-del Castillo, Andrew L. Warshaw, Kimberly A. Kelly, Sarah P. Thayer

Research output: Contribution to journalArticle

38 Scopus citations


Introduction Pancreatic intraductal papillary mucinous neoplasms (IPMN) are now identified with increasing frequency. The detection of carcinoma in IPMN is difficult and suffers from high false-positive and false-negative rates, often resulting in inappropriate treatment decisions. Improved detection of malignancy using novel biomarkers may therefore improve diagnostic accuracy. One such promising novel biomarker is Plectin-1 (Plec-1). Methods Using immunohistochemistry, Plec-1 expression was assayed in benign (low and moderate dysplasia, n=6) as well as malignant IPMN (high-grade dysplasia and invasive carcinoma, n=31) and lymph node metastases from carcinoma arising in IPMN (n=12). Furthermore, cyst fluids from benign (n=3) and malignant IPMN (n=4) were evaluated for Plec-1 expression. Results and discussion Twenty-six of 31 malignant IPMN and all 12 lymph node metastases were Plec-1 positive. In contrast, only one of six benign IPMN expressed Plec-1. The specificity of Plec-1 in distinguishing malignant IPMN from benign IPMN was 83% and its sensitivity 84%. Furthermore, all (four out of four) cyst fluids from malignant IPMN, but one of the three benign IPMN, were Plec-1 positive. These data support Plec-1 as an excellent biomarker for the early etection of carcinoma arising in IPMN.

Original languageEnglish (US)
Pages (from-to)1948-1954
Number of pages7
JournalJournal of Gastrointestinal Surgery
Issue number11
StatePublished - Sep 18 2009


  • Biomarker
  • Malignant IPMN
  • Plectin-1

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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    Bausch, D., Mino-Kenudson, M., Fernández-del Castillo, C., Warshaw, A. L., Kelly, K. A., & Thayer, S. P. (2009). Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms. Journal of Gastrointestinal Surgery, 13(11), 1948-1954.