Pluronic® block copolymers: Novel functional molecules for gene therapy

Alexander V. Kabanov, Pierre Lemieux, Sergey Vinogradov, Valery Alakhov

Research output: Contribution to journalArticle

274 Scopus citations

Abstract

Pluronic® block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. They have been used extensively in a variety of pharmaceutical formulations including delivery of low molecular mass drugs and polypeptides. This review describes novel applications of Pluronic® block copolymers in gene therapy. In particular, these molecules can modify the biological response during gene therapy in the skeletal muscle, resulting in an enhancement of the transgene expression as well as an enhancement of the therapeutic effect of the transgene. Furthermore, Pluronic® block copolymers are versatile molecules that can be used as structural elements of the polycation-based gene delivery systems (polyplexes). Based on these studies, the use of block copolymers in gene delivery is a promising area of research, in which new and important developments are expected.

Original languageEnglish (US)
Pages (from-to)223-233
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume54
Issue number2
DOIs
StatePublished - Feb 21 2002

Keywords

  • Block copolymer
  • DNA
  • Gene delivery
  • Gene therapy
  • Poly(ethylene glycol)
  • Polycation

ASJC Scopus subject areas

  • Pharmaceutical Science

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