Polyamines and platelet aggregation

Owen Rennert; Bruce Buehler; Thomas Miale; Daniel Lawson

doi:10.1016/0024-3205(76)90398-2

Polyamines and platelet aggregation

Owen Rennert, Bruce Buehler, Thomas Miale, Daniel Lawson

Genetic Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

Original language	English (US)
Pages (from-to)	257-264
Number of pages	8
Journal	Life Sciences
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(76)90398-2
State	Published - Jul 15 1976

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Polyamines and platelet aggregation",

abstract = "High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.",

author = "Owen Rennert and Bruce Buehler and Thomas Miale and Daniel Lawson",

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AU - Miale, Thomas

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AB - High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

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