Polyamines and platelet aggregation

Owen Rennert; Bruce Buehler; Thomas Miale; Daniel Lawson

doi:10.1016/0024-3205(76)90398-2

Polyamines and platelet aggregation

Owen Rennert, Bruce Buehler, Thomas Miale, Daniel Lawson

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

Original language	English (US)
Pages (from-to)	257-264
Number of pages	8
Journal	Life Sciences
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(76)90398-2
State	Published - Jul 15 1976
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(76)90398-2

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title = "Polyamines and platelet aggregation",

abstract = "High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.",

author = "Owen Rennert and Bruce Buehler and Thomas Miale and Daniel Lawson",

note = "Funding Information: The authors acknowledge with thanks the support of the National Institutes of Health Training Grant No . A1{\^i}05680-05, the National Cystic Fibrosis Research Foundation, and Boehringer-Mannheim.",

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doi = "10.1016/0024-3205(76)90398-2",

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T1 - Polyamines and platelet aggregation

AU - Rennert, Owen

AU - Buehler, Bruce

AU - Miale, Thomas

AU - Lawson, Daniel

N1 - Funding Information: The authors acknowledge with thanks the support of the National Institutes of Health Training Grant No . A1î05680-05, the National Cystic Fibrosis Research Foundation, and Boehringer-Mannheim.

PY - 1976/7/15

Y1 - 1976/7/15

N2 - High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

AB - High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

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U2 - 10.1016/0024-3205(76)90398-2

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VL - 19

SP - 257

EP - 264

JO - Life Sciences

JF - Life Sciences

IS - 2

ER -

Polyamines and platelet aggregation

Abstract

ASJC Scopus subject areas

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