Polyamines and platelet aggregation

Owen Rennert, Bruce Buehler, Thomas Miale, Daniel Lawson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


High blood concentrations of the naturally occurring polyamines have been reported in leukemia, psoriasis, cystic fibrosis and polycythemia rubra vera. Spermidine and spermine inhibit in vitro plate-let aggregation of platelet rich plasma preparations in which ADP and Ristocetin are the agglutinating agents. The proposal is made that these organic cations may modulate in vivo platelet agglutinability.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalLife Sciences
Issue number2
StatePublished - Jul 15 1976
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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