Polymer-based vehicles for therapeutic peptide delivery

Jinjin Zhang, Swapnil S. Desale, Tatiana K. Bronich

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

During the last decades increasing attention has been paid to peptides as potential therapeutics. However, clinical applications of peptide drugs suffer from susceptibility to degradation, rather short circulation half-life, limited ability to cross physiological barriers and potential immunogenicity. These challenges can be addressed by using polymeric materials as peptide delivery systems, owing to their versatile structures and properties. A number of polymer-based vehicles have been developed to stabilize the peptides and to control their release rates. Unfortunately, no single polymer or formulation strategy has been considered ideal for all types of peptide drugs. In this review, currently used and potential polymer-based systems for the peptide delivery will be discussed.

Original languageEnglish (US)
Pages (from-to)1279-1296
Number of pages18
JournalTherapeutic Delivery
Volume6
Issue number11
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Pharmaceutical Science

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