Polymer brushes as active nanolayers for tunable bacteria adhesion

Bogdan Zdyrko, Viktor Klep, Xiaowei Li, Qian Kang, Sergiy Minko, Xuejun Wen, Igor Luzinov

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Bacterial biofilm formation on implant surfaces is a frequent reason for the failure of many biomedical devices. Polymer brushes, thin nanolayers constituted of densely grafted macromolecules, are promising candidates to use in many biomedical applications to control attachment of bacteria to a surface. In this work five different polymer brushes were synthesized and tested with respect to their ability to regulate Staphylococcus aureus adhesion. Namely, two mixed brushes [consisting of poly(ethylene glycol) and a positively charged polymers, poly(2-vynil pyridine) or quartenized poly(2-vynil pyridine)] are investigated along with one-component brushes of the respective polymers. Bacterial adhesion was regulated over two orders of magnitude via altering the polymer brush composition.

Original languageEnglish (US)
Pages (from-to)680-684
Number of pages5
JournalMaterials Science and Engineering C
Volume29
Issue number3
DOIs
StatePublished - Apr 30 2009

Keywords

  • PEG
  • PGMA
  • bacteria adhesion
  • bacteria-centered infection
  • biofilm
  • polymer brush

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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