Polymeric nanogel formulations of nucleoside analogs

Serguei V. Vinogradov

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Nanogels are colloidal microgel carriers that have been recently introduced as a prospective drug delivery system for nucleotide therapeutics. The crosslinked protonated polymer network of nanogels binds oppositely charged drug molecules, encapsulating them into submicron particles with a core-shell structure. The nanogel network also provides a suitable template for chemical engineering, surface modification and vectorisation. This review reveals recent attempts to develop novel drug formulations of nanogels with antiviral and antiproliferative nucleoside analogs in the active form of 5′-triphosphates, discusses structural approaches to the optimisation of nanogel properties, and discusses the development of targeted nanogel drug formulations for systemic administration. Notably, nanogels can improve the CNS penetration of nucleoside analogs that are otherwise restricted from passing across the blood-brain barrier. The latest findings reviewed here demonstrate an efficient intracellular release of nucleoside analogs, encouraging further applications of nanogel carriers for targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)5-17
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume4
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Accumulation enhancement
  • Drug delivery
  • Nucleoside 5′-triphosphates
  • Polymeric microgels
  • Structural modification
  • Triggered drug release
  • Vectorisation

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Polymeric nanogel formulations of nucleoside analogs'. Together they form a unique fingerprint.

Cite this