Polymorphism of Saccharomyces cerevisiae Strains in DNA Metabolism Genes

Anna S. Zhuk, Artem G. Lada, Youri I. Pavlov

Research output: Contribution to journalArticlepeer-review


Baker’s yeast, S. cerevisiae, is an excellent model organism exploited for molecular genetic studies of the mechanisms of genome stability in eukaryotes. Genetic peculiarities of commonly used yeast strains impact the processes of DNA replication, repair, and recombination (RRR). We compared the genomic DNA sequence variation of the five strains that are intensively used for RRR studies. We used yeast next-generation sequencing data to detect the extent and significance of variation in 183 RRR genes. We present a detailed analysis of the differences that were found even in closely related strains. Polymorphisms of common yeast strains should be considered when interpreting the outcomes of genome stability studies, especially in cases of discrepancies between laboratories describing the same phenomena.

Original languageEnglish (US)
Article number7795
JournalInternational journal of molecular sciences
Issue number9
StatePublished - May 2023


  • DNA recombination
  • DNA repair
  • DNA replication
  • genetic polymorphism
  • genome sequence
  • yeast Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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