Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk

Rick J. Jansen, Dennis P. Robinson, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Xianglin Tan, Julie M. Cunningham, Ying Li, David N. Rider, Ann L. Oberg, Kari G. Rabe, Kristin E. Anderson, Rashmi Sinha, Gloria M. Petersen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objectives: A source of variation for inconsistent dietary-pancreatic cancer associations may be individuals carrying constitutional metabolism/antioxidant gene variants that differentially benefit compared to homozygous individuals. Seventy-six tag single-nucleotide polymorphisms were genotyped in 13 candidate genes to test differential associations with pancreatic adenocarcinoma. Methods: A clinic-based case-control design was used to rapidly ascertain 251 cases and 970 frequency matched controls who provided blood samples and completed a 144-item food frequency questionnaire. Single-nucleotide polymorphisms were evaluated using a dominant genetic model and dietary categories split on controls' median intake. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusted for potential confounders. Results: Significant increased associations (Bonferroni corrected P ≤ 0.0007) were observed for carriers of greater than or equal to 1 minor allele for rs3816257 (glucosidase, α; acid [GAA]) and lower intake of deep-yellow vegetables (1.90 [1.28-2.83]); and carriers of no minor allele for rs12807961 (catalase [CAT]) and high total grains intake (2.48 [1.50-4.09]), whereas those with greater than or equal to 1 minor allele had a decreasing slope (across grains). The reference group was no minor alleles with low dietary intake. Conclusions: Interindividual variation in metabolism/antioxidant genes could interact with dietary intake to influence pancreatic cancer risk.

Original languageEnglish (US)
Pages (from-to)1043-1053
Number of pages11
JournalPancreas
Volume42
Issue number7
DOIs
StatePublished - Oct 2013

Keywords

  • case-control
  • dietary risk factors
  • genetic risk factors
  • interaction
  • pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint Dive into the research topics of 'Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk'. Together they form a unique fingerprint.

  • Cite this

    Jansen, R. J., Robinson, D. P., Stolzenberg-Solomon, R. Z., Bamlet, W. R., Tan, X., Cunningham, J. M., Li, Y., Rider, D. N., Oberg, A. L., Rabe, K. G., Anderson, K. E., Sinha, R., & Petersen, G. M. (2013). Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. Pancreas, 42(7), 1043-1053. https://doi.org/10.1097/MPA.0b013e3182968e00