Porous structures from fibrous proteins for biomedical applications

Helan Xu, Yiqi Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Porous protein structures render biomaterials similar to their natural counterparts, extracellular matrices (ECMs), regarding both structure and material. Proteins in fibrous form have attracted considerable attention for fabrication of porous structures, as ECMs are composed of nanoscale protein fibers oriented randomly in three dimensions. Pores or voids created by random arrangements of the fibers provide spaces for cells to grow and spread. Fibrous structures could further facilitate cell attachment and guide cellular development and signaling. As technical difficulties have been gradually tackled, developing fibrous proteinous structures as biomaterials are arousing more interests. Micro- and nanofibrous structures have been developed from animal proteins, e.g., collagen, fibroin, keratin, and plant proteins, e.g., zein, soyprotein, and wheat gluten, via wet spinning, electrospinning, phase separation and other approaches. However, proteins as biomaterials usually suffer from inferior water stability, fast degradation, and poor mechanical properties. To circumvent these problems, crosslinking approaches have been applied, or synthetic polymers have been incorporated to improve the performance properties of proteins in aqueous environments.

Original languageEnglish (US)
Title of host publicationPorous Lightweight Composites Reinforced with Fibrous Structures
PublisherSpringer Berlin Heidelberg
Pages159-177
Number of pages19
ISBN (Electronic)9783662538043
ISBN (Print)9783662538029
DOIs
StatePublished - Aug 22 2017

Keywords

  • Biomedical applications
  • Crosslinking
  • Electrospinning
  • Phase separation
  • Porous structures
  • Protein fibers

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

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  • Cite this

    Xu, H., & Yang, Y. (2017). Porous structures from fibrous proteins for biomedical applications. In Porous Lightweight Composites Reinforced with Fibrous Structures (pp. 159-177). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-53804-3_7