Positive and negative selection on the mitochondrial genome

Colin D. Meiklejohn, Kristi L. Montooth, David M. Rand

Research output: Contribution to journalShort surveypeer-review

275 Scopus citations


Several recent studies have confirmed that mitochondrial DNA variation and evolution are not consistent with the neutral theory of molecular evolution and might be inappropriate for estimating effective population sizes. Evidence for the action of both positive and negative selection on mitochondrial genes has been put forward, and the complex genetics of mitochondrial DNA adds to the challenge of resolving this debate. The solution could lie in distinguishing genetic drift from 'genetic draft' and in dissecting the physiology of mitochondrial fitness.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalTrends in Genetics
Issue number6
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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