Possible genotoxic modes of action for naphthalene

David Brusick, Mitchell S. Small, Ercole L. Cavalieri, Dhrubajyoti Chakravarti, Xinxin Ding, David G. Longfellow, Jun Nakamura, Eleanor C. Rogan, James A. Swenberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalRegulatory Toxicology and Pharmacology
Volume51
Issue number2 SUPLL
DOIs
StatePublished - Jul 2008

Keywords

  • 1,2-Naphthoquinone
  • Biomarkers
  • Cancer
  • Carcinogenicity
  • DNA adducts
  • Depurinating adducts
  • Genotoxicity
  • Mechanism of action
  • Metabolism
  • Mode of action
  • Mutagenicity
  • Naphthalene
  • Stable adducts

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Brusick, D., Small, M. S., Cavalieri, E. L., Chakravarti, D., Ding, X., Longfellow, D. G., Nakamura, J., Rogan, E. C., & Swenberg, J. A. (2008). Possible genotoxic modes of action for naphthalene. Regulatory Toxicology and Pharmacology, 51(2 SUPLL), 43-50. https://doi.org/10.1016/j.yrtph.2007.12.002