Possible genotoxic modes of action for naphthalene

David Brusick; Mitchell S. Small; Ercole L. Cavalieri; Dhrubajyoti Chakravarti; Xinxin Ding; David G. Longfellow; Jun Nakamura; Eleanor C. Rogan; James A. Swenberg

doi:10.1016/j.yrtph.2007.12.002

Possible genotoxic modes of action for naphthalene

David Brusick, Mitchell S. Small, Ercole L. Cavalieri, Dhrubajyoti Chakravarti, Xinxin Ding, David G. Longfellow, Jun Nakamura, Eleanor C. Rogan, James A. Swenberg

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS³), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.

Original language	English (US)
Pages (from-to)	43-50
Number of pages	8
Journal	Regulatory Toxicology and Pharmacology
Volume	51
Issue number	2 SUPLL
DOIs	https://doi.org/10.1016/j.yrtph.2007.12.002
State	Published - Jul 2008

Keywords

1,2-Naphthoquinone
Biomarkers
Cancer
Carcinogenicity
DNA adducts
Depurinating adducts
Genotoxicity
Mechanism of action
Metabolism
Mode of action
Mutagenicity
Naphthalene
Stable adducts

ASJC Scopus subject areas

Toxicology

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10.1016/j.yrtph.2007.12.002

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@article{4df3db8e56e042fea2940b4d22c69623,

title = "Possible genotoxic modes of action for naphthalene",

abstract = "This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.",

keywords = "1,2-Naphthoquinone, Biomarkers, Cancer, Carcinogenicity, DNA adducts, Depurinating adducts, Genotoxicity, Mechanism of action, Metabolism, Mode of action, Mutagenicity, Naphthalene, Stable adducts",

author = "David Brusick and Small, {Mitchell S.} and Cavalieri, {Ercole L.} and Dhrubajyoti Chakravarti and Xinxin Ding and Longfellow, {David G.} and Jun Nakamura and Rogan, {Eleanor C.} and Swenberg, {James A.}",

note = "Funding Information: Additional grant support was provided by the Electric Power Research Institute, the American Petroleum Institute, the Naphthalene Council, Inc., the Association of Railroads, the American Coke and Coal Chemicals Institute, the Asphalt Institute, and the National Petrochemical Refiners Association. It has not been reviewed by any of these sponsors, and does not necessarily represent their views. Funding Information: This article was developed in part under EPA Assistance Agreement No. 83330401-0 awarded by the U.S. Environmental Protection Agency. It has not been formally reviewed by the EPA. The views expressed in this document are solely those of the authors and the EPA does not endorse any products or commercial services mentioned in this publication. ",

year = "2008",

month = jul,

doi = "10.1016/j.yrtph.2007.12.002",

language = "English (US)",

volume = "51",

pages = "43--50",

journal = "Regulatory Toxicology and Pharmacology",

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T1 - Possible genotoxic modes of action for naphthalene

AU - Brusick, David

AU - Small, Mitchell S.

AU - Cavalieri, Ercole L.

AU - Chakravarti, Dhrubajyoti

AU - Ding, Xinxin

AU - Longfellow, David G.

AU - Nakamura, Jun

AU - Rogan, Eleanor C.

AU - Swenberg, James A.

N1 - Funding Information: Additional grant support was provided by the Electric Power Research Institute, the American Petroleum Institute, the Naphthalene Council, Inc., the Association of Railroads, the American Coke and Coal Chemicals Institute, the Asphalt Institute, and the National Petrochemical Refiners Association. It has not been reviewed by any of these sponsors, and does not necessarily represent their views. Funding Information: This article was developed in part under EPA Assistance Agreement No. 83330401-0 awarded by the U.S. Environmental Protection Agency. It has not been formally reviewed by the EPA. The views expressed in this document are solely those of the authors and the EPA does not endorse any products or commercial services mentioned in this publication.

PY - 2008/7

Y1 - 2008/7

N2 - This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.

AB - This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties.

KW - 1,2-Naphthoquinone

KW - Biomarkers

KW - Cancer

KW - Carcinogenicity

KW - DNA adducts

KW - Depurinating adducts

KW - Genotoxicity

KW - Mechanism of action

KW - Metabolism

KW - Mode of action

KW - Mutagenicity

KW - Naphthalene

KW - Stable adducts

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U2 - 10.1016/j.yrtph.2007.12.002

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AN - SCOPUS:44649167248

SN - 0273-2300

VL - 51

SP - 43

EP - 50

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

IS - 2 SUPLL

ER -

Possible genotoxic modes of action for naphthalene

Abstract

Keywords

ASJC Scopus subject areas

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